What does it take to understand how cells communicate and organize themselves into a functioning organism?

In this episode of The Curious Mindset, we sit down with Dr. Spyros Artavanis-Tsakonas, 2025 recipient of the Canada Gairdner International Award, to explore his pioneering work on the Notch signalling pathway and its impact on developmental biology. From the model organisms that helped unlock fundamental biological questions to the technologies shaping the future of science, Dr. Artavanis-Tsakonas reflects on what continues to fascinate him about discovery.

We also discuss the importance of choosing the right people, creating supportive research environments, and giving scientists the freedom to fail and follow their curiosity.

Beyond the science, Dr. Artavanis-Tsakonas shares his thoughts on the future of science, as well as his passions for fishing, painting, and lifelong curiosity.